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with a similar result : for a few days the urine was free, but now contains albumin again to the amount of three fourths gramme (Esbach), one half the quantity before treatment. The other case was one of marked ascites w-ith albumin four and a half grammes (Esbach). .Although the patient material- ly improved, and the albumin was reduced to one gramme, the condition remained stationary, and a second injection is tinder advisement. .\n orchitis, in the patient with malignant syph- ilis cited before, was reduced to about one third in five weeks. I have been able to make some comparisons on the use of salvarsan with mercury and potassium iodide in certain specific affections of the nervous system, which would seem to give the drug a place in the therapeutics of many of these seemingly hope- less cases. Its influence is especially gratifying in severe headaches which have been treated for a long time with the old remedies without any mate- rial benefit. In a number of these a decided ameli- oration was produced by a single injection or a combination of salvarsan and mercury. In a patient with spastic paralysis of the Erb type, a marked improvement in his general condition and gait took place after an injection of 0.6 gramme alkaline solu- tion. A second intravenous injection, about ten weeks later, has as yet exercised no additional influence either on his condition or serum reaction. On January nth, I treated a patient, who for the past ten years had Best Place To Buy Viagra Online Canada been subject to epileptiform attacks, with 0.4 gramme intramuscularly, followed a week later by the same dose intravenously. He has had no seizures since, is in good health and able to pursue his occupation. His scrum reaction is also negative. It may be of interest Best Place To Buy Viagra Online Canada here to add a note to the history previously reported of a professional man who was suf- fering from symptoms pointing to an endarteritis of the base of the brain involving both pyramidal tracts and the sympathetic. He was treated on August ,vst with 0.45 gramme, on October i6th with 0.5 gramme, and since that rime his physician has administered a third dose. Re- covery has steadily taken place during the past seven months, his health is now good, and he is able to dis- charge the duties connected with his profession. Except in isolated cases the treatment of tabes has not been very encouraging, T have, however, been able to draw some rather definite conclusions as to the indications for the use of the drug in this con- dition. Patients with tabes who come to treatment may be divided into two groups: Those of years' 864 FORDYCE: SALVAKSAN. [New York edical journai, Standing which have been treated vigorously with mercury and potassium iodide, whose Wassermann reaction is slightly positive or negative, and whose cerebrospinal fluid contains no increase or a very slight one of lymphocytes. In these cases the ad- ministration of salvarsan accomplishes little or nothing. In the other class, with a strongly posi- tive reaction, marked lymphocytosis of the spinal fluid, and globulin increase, characteristic pains with gastric or other crises, and little or no im- pairment of the gait, the probabilities of relieving the pain or arresting the progress of the disease seem to me to justify the use of the remedy. In several patients of this latter class there has been an improvement in the pains, the gastric crises, and their general well being. Ehrlich advises that in these cases the drug be given in small doses, re- Best Place To Buy Viagra Online Canada peated at certain definite intervals. Although he distinctly warns against using it in advanced de- generative disease of the nervous system, I have personally seen no harm to advanced tabetics to whom doses of from 0.4 gramme to 0.6 gramme have been given. The only unpleasant effect noted has been an aggravation of the neuralgic pains, sometimes persisting for a week or ten days. As an illustration of the benefit that may ensue from the use of salvarsan in certain types of tabes, I cite the following cases: Mr. X.. aged forty-nine years ; infection in 18S4, lor which he had irregular and insufficient treatment. I'ains in his legs began twelve years ago. When seen in No- vember examination showed absence of left knee jerk, right responding slightly ; pupils almost Argyll Robertson condition; gait very little impaired; pains marked; Was- sermann reaction -\ — (-. On December 12th he received 0.6 gramme salvarsan intramuscularly. A diary kept by the patient for thirty-six days after he returned home re- Best Place To Buy Viagra Online Canada ports five bad days, eleven with some pain, and twenty free from pain. His serum Best Place To Buy Viagra Online Canada reaction is now negative, and he states that he is feeling better and suffers from only occasional twinges of pain. Mr. Y. Primary and secondaries two and a half years ago. Last .'Vugust a third nerve paresis, double vision, and unequal pupils developed ; both respond to light and accommodation. His gait became impaired, especially in going up and down stairs; his knee jerks were weak, sex- ual power lessened and bladder continence insufficient. Notwithstanding thirty injections of mercury bichloride, from one third to one half grain, every other day, there was little or no change in his condition. After the admin- istration of salvarsan a marked improvement took place in the symptoms enuinerated. At the end of a month his knee jerks were practically normal, his double vision dis- appeared, he gained twenty pounds in weight, and stated that his mind was much clearer, the depression he had suffered from was gone, and his business energy had re- turned. I have also administered the drug Best Place To Buy Viagra Online Canada in several cases in the early stage of paresis with but indif- ferent results, excepting in the following case: Best Place To Buy Viagra Online Canada This patient, aged thirty-five years, contracted syphilis fifteen years ago, for which he was treated for three years. Fourteen years ago an iritis of the left eye developed, the adhesions of which remain. He had no further symp-